Consortium Initiates the Project MACYA – Molecular Atlas of Cancer in Young Adults
During the recent seminar from 18.09.2024, the Consortium prepared a consensus statement that points to further study directions. In particular, it was mentioned that the Сonsortium’s scope should be expanded and research should begin on the problem of “young” cancer in general.
Revealing molecular mechanisms of early-onset tongue cancer by spatial transcriptomics
The article «Revealing molecular mechanisms of early-onset tongue cancer by spatial transcriptomics» prepared by EPOY has been published in the Scientific Reports. Using spatial transcriptomics technology and single cell full-length RNA sequencing, we found that tongue cancer in young adults has a distinct spatial transcriptomic features and molecular mechanisms compared to older patients. Early-onset tongue […]
EPOY consortium results won the Best Poster Presentation Award on International Conference KSMO 2024
Dr. Elena Kolegova presented the poster “Multi-omics of early-onset oral cancer” at the 17th Annual Meeting of the Korean Society of Medical Oncology & 2024 International Conference (KSMO 2024), which was held on September 26-27, 2024 in Seoul, South Korea. This poster presented ongoing results in mutational, transcriptome and metagenome landscape of early-onset oral cancer, […]
Meeting of the Consortium members was held in Moscow at the VII International Forum of Oncology and Radiotherapy “For Life”
Consortium members met at the Workshop “Early-onset cancer: biological and clinical features” during the VII International Forum of Oncology and Radiotherapy “ForLife” to discuss the latest advances in the field of cancer in young adults. It is known that cancer at a young age is a nationwide problem that is being raised not only in […]
Genetic features of tongue cancer recurrence in young adults
EPOY published the article «Genetic features of tongue cancer recurrence in young adults» in the Bulletin of Experimental Biology and Medicine. In this study, we identified specific single-nucleotide and copy number alterations, for example, mutations in the TP53 and EPHB6 genes, which could be a cause of recurrence of tongue cancer in young adults. In […]
The results of the EPOY’s work were presented on the YouTube channel
Dr. Denisov presented a talk “Unlocking secrets of early-onset oral cancer by multi-omics” on the YouTube channel “Oral Pathology 360” as part of the Oral Pathology Tuesdays program, where oral-pathology, medicine and radiology are discussed every week. Dr. Denisov revealed the secrets of early-onset oral cancer through the powerful lens of multi-omics. All data presented […]
Consortium members will meet in Moscow at the VII International Forum of Oncology and Radiotherapy “ForLife”
On September 16 – 20, 2024, EPOY consortium members will meet for a seminar to discuss the latest advances at the VII International Forum of Oncology and Radiotherapy “ForLife”.
Joining of the Central Research Institute of Dental and Maxillofacial Surgery
The Central Research Institute of Dental and Maxillofacial Surgery has joined the EPOY! The Institute has shared to the EPOY research mission. Federal State Institution Central Research Institute of Dental and Maxillofacial Surgery
Contrasting clinical outcomes and socio-economic impact of young versus elderly-onset oral squamous cell carcinoma, a novel health economic analysis
In a cohort of 2138 oral cancer patients from Singapore and India, Singh M. et al. demonstrated that young adults had a pathologically more aggressive form of oral cancer, although 5-year overall and disease specific survival did not differ between younger and older patients due to more intensive therapy. Nevertheless, the loss of life from […]
Molecular mechanisms of early-onset tongue cancer
The article «Revealing molecular mechanisms of early-onset tongue cancer by spatial transcriptomics» prepared by EPOY has been published on bioRxiv. Using spatial transcriptomics technology, we showed that early-onset tongue cancer is enriched by oxidative stress, vascular mimicry, and MAPK and JAK-STAT signaling pathways. Tumor microenvironment demonstrated increased gene signatures corresponding to myeloid-derived suppressor cells, tumor-associated […]