The colleagues from China have published an article about a connection of oral microbiota dysbiosis and oral squamous cell cancer (OSCC) progression in young patients. The study revealed compositional and functional differences between the microbiota of OSCC tissues from young and elderly subjects: Ochrobactrum, Prevotella, and Ralstonia were enriched in the young OSCC microbiota and may promote tumorigenesis by causing inflammation and opportunistic infection. Also from the view of functional prediction, the microbiota of young OSCC patients was more enriched in the degradation of antitumor components and increased oxidative stress.