Classic factors of oral cancer, such as tobacco, alcohol, and HPV-positive status, are not associated with the development of oral cancer at a young age. The association of early-onset oral cancer with smokeless tobacco is confirmed by the studies conducted in regions with a high prevalence of chewing tobacco and betel nut, such as India, Pakistan, and Yemen Therefore, there are insufficient global results at this time to accurately validate the etiological factors of cancer in young adults, so EPOY initiates the epidemiological study of early onset oral cancer incidence.