The article «Revealing molecular mechanisms of early-onset tongue cancer by spatial transcriptomics» prepared by EPOY has been published on bioRxiv. Using spatial transcriptomics technology, we showed that early-onset tongue cancer is enriched by oxidative stress, vascular mimicry, and MAPK and JAK-STAT signaling pathways.
Tumor microenvironment demonstrated increased gene signatures corresponding to myeloid-derived suppressor cells, tumor-associated macrophages, and plasma cells. The invasive front was accompanied by vascular mimicry with arrangement of tumor-associated macrophages and aggregations of plasma cells and lymphocytes organized into tertiary lymphoid structures.