The article «Revealing molecular mechanisms of early-onset tongue cancer by spatial transcriptomics» prepared by EPOY has been published in the Scientific Reports.
Using spatial transcriptomics technology and single cell full-length RNA sequencing, we found that tongue cancer in young adults has a distinct spatial transcriptomic features and molecular mechanisms compared to older patients. Early-onset tongue tumor core is characterized by an increased number of immunosuppressive cells and activation of the MAPK and TGFb signaling pathways. The invasive tumor front is enriched lymphocytes with antitumor cytotoxic activity and accompanied by vascular mimicry with arrangement of tumor-associated macrophages.
Thus, early-onset tongue cancer should be considered a separate clinical form with specific treatment, post-treatment follow-up tactics, and prognosis.